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Patrinostro, X., Carter, M

Malabsorption (insufficient intake of vitamin B12in the intestine) due to insufficient production of intrinsic factor (a protein that is formed in the gastric mucosa and is required for the absorption of vitamin B12), Diseases in the end section of the ileum (part of the small intestine), e.g

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The absence of CRY has been hypothesized to release its inhibition on cAMP production, thereby increasing cAMP levels and PKA activation and, subsequently, PKA-mediated phosphorylation of the p65 subunit of NF-B, leading to its constitutive activation