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System Xc GPX4 pathway The system Xc GPX4 pathway is a key intracellular antioxidant and antiferroptosis mechanism [28, 29]

Figure 1 Statements Author contributions SO: Writing review & editing, Writing original draft, Investigation, Conceptualization

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Nucleophilic attack and cleavage of the phenoxy group require that the phosphoryl group of ACPB be aligned in the active site of the enzyme in a way that allows close contact between the Thr-381 side-chain OG and the phosphorus atom of ACPB