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The abnormal expression of GPx2 was detected in different tumors, and GPx2 was up-regulated in colorectal cancer [51, 52] and down-regulated in prostate intraepithelial neoplasia [53], suggesting that GPx2 plays complex roles in tumorigenesis [23]

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As previously mentioned, lactate exists as two stereoisomers, L-lactate and D-lactate, both of which are transported between intracellular and extracellular environments by the MCTs family [39]