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This stress can cause a decrease in the production of inflammatory cytokines like TNF- and interleukins (such as IL-6, IL-10, and IL-1), ultimately leading to the death of these cells

All these cellular alterations are associated with ECD

Some studies have found that M10 exerts higher activities in preventing UC through inhibiting necroptosis [143] however, it has also been demonstrated that the majority of M10 is metabolized to myricetin via fecal microbiota and that both compounds are mostly located in inflamed tissues, exerting their immunomodulatory actions [144]

Beneficial effects of silibinin on serum lipids, bile acids, and gut microbiota in methionine-choline-deficient diet-induced mice