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Mod Rheumatol

No published research has demonstrated cancer promotion in any animal or human study

The beneficial effect of this plant can be attributed to the existence of various phytoconstituents in the seeds, including phenolic compounds (such as quercetin), alkaloids, phytosterols (such as -sitosterol), saponins, glucosides (such as -galactosidases and -mannosides) [39,40]

In addition to DNAm, cigarette smoking is linked to the activation of enzymes that regulate other types of epigenetic modifications (i.e., post-translational modifications of histones via methylation, acetylation, phosphorylation, ubiquitination, and regulation of non-coding RNA sequences) to mediate the expression of multiple inflammatory genes, thereby participating in the onset development of autoinflammatory diseases (135)