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suggested that Sanguinarine aggregated excessive ROS by promoting the activation of NOX3 and consequential inactivation of MsrA and Cys peroxidation of EGFR T790M in EGFR-modulated TKI-resistant cells, which ultimately led to EGFR degradation and cell death 284 (Table 1, Fig

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2 Placebo IM injection and an oral placebo were given to maintain blinding 1 Paliperidone palmitate, a known and effective treatment, served as an active control