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Circulating insulin-like growth factors and related binding proteins are selectively altered in amyotrophic lateral sclerosis and multiple sclerosis

Research published in the New England Journal of Medicine has shown that time-restricted eating can improve metabolic health, reduce inflammation, and support weight loss when combined with overall calorie management

An update on cobalamin deficiency in adults

However, because IGF-1 signaling operates through cellular proliferation pathways also implicated in oncogenic processes, published protocols consistently list active or precancerous conditions as contraindications requiring exclusion from study populations.