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The Endocrine Society's 2020 clinical practice guidelines on trace mineral supplementation recommend that "any exogenous copper-containing therapeutic, including peptide-bound formulations, should be accompanied by periodic serum copper and hepatic function assessment at intervals no longer than 6 months" [9]

The modification involves substituting specific amino acids to enhance the stability and effectiveness of the peptide

Hossenlopp P, Segovia B, Lassarre C, Roghani M, Bredon M, Binoux M

Interestingly, there were other groups whose research noted that the molecule appeared to cause arousal in the first hour of sleep, followed by sedation in the second hour of sleep