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Ordinarily, however, this toxic metabolite is rendered harmless (detoxified) by another pathway, the glutathione system

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[92] showed that NAC infusion at 100 mg/kg over 2 h, in combination with calmangafodipir, a superoxide dismutase mimetic, could be well tolerated and reduce biomarkers of paracetamol toxicity such as ALT, keratin-18, and circulating caspase-cleaved cytokeratin-18 in patients with paracetamol overdose

25 Nevertheless, it is important to note that the atherosclerotic process often begins in childhood, particularly in children with overweight and obesity and those with high blood glucose levels