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Children with ASD also have significant decreases in methionine levels and the ratio of plasma S-adenosylmethionine (SAM) to S-adenosylhomocysteine (SAH) (SAM: SAH ratio), an index of methylation capacity ( Most importantly, children with ASD also have decreased levels of total glutathione and the reduced or active form of glutathione ( Although prior nutritional interventions addressing antioxidant capacity have successfully improved glutathione levels, the association between these changes and autistic behavior has been less compelling

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According to Du Plessis and his coworkers [17], both Ca 2+ ions and ROS are involved in the initiation of the capacitation to cause the activation of adenylate cyclase which results in the production of cyclic adenosine monophosphate (cAMP)