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Other antiretroviral classes, including non-nucleoside reverse transcriptase inhibitors (NNRTIs) and protease inhibitors (PIs), do not directly inhibit Pol- but are still associated with mitochondrial dysfunction through alternative mechanisms (107, 108)

The results suggest that the ascorbic acid treatment has minimal effects on the viability of the cells cultured in the spheroid format, which is different from the observation in the single cell experiments

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However, it's important to remember there are many factors that influence our BAC, and these tools only help us estimate it