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Twelve-week old female C57/BL6J mice were individually housed in specific pathogen-free conditions with sterile ventilator cages containing corn bedding, with ad libitum access to chow and water

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Small molecular kinase inhibitors can block phosphorylation of the catalytic domain in the receptor by competitive or non-competitive antagonism of the ATP binding site, thereby preventing the recruitment of signal transducers and mediators, and thus impeding the transmission of downstream signals (Munshi et al., 2010

The 2016 Draft Guidance has been criticized by industry and trade associations for its lack of clarity and other problems