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Face au alpha-MSH naturel (hormone endogene), le MT-2 est approximativement 1000 fois plus puissant in vitro grace a la cyclisation et a la D-substitution, et presente une demi-vie plasmatique de 33 heures contre moins de 10 minutes pour l'alpha-MSH natif

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MT-2, on the other hand, affects a broader range of receptors, producing quicker and more intense tanning, while also having effects on appetite, metabolism, and sexual function