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43 A number of other animal model studies have also demonstrated that genetic deficiency in negative regulators of the canonical NF-B pathway, such as the deubiquitinases CYLD and A20, promotes colonic inflammation

Different host-tissue microenvironments select for cancer cells with distinct metastatic traits, which gives rise to organ-specific populations of metastatic cells [14]

Such integrative analyses have revealed correlations between gut microbiota signatures, clinical outcomes, and BA profiles in cancer and related inflammatory conditions (126, 139, 173)

As an alternative therapy, adults may undergo gastric lavage within 1 hour of taking a potentially life-threatening dose