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47 Its prevalence has been increasing with time and is currently estimated to be around 0.01 to 0.02 per 100,000 people in the population as a whole

Furthermore, spermidines impact on neurogenesis and synaptic plasticity suggests its potential to mitigate age-related cognitive decline and improve memory function in both animals and humans (Reference Schwarz, Horn and Benson19)

WB revealed that the protein levels of HDAC1, HDAC2, and HDAC6 increased and that the protein level of ILF3 decreased after stimulation with different concentrations of simvastatin (Fig