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10,11 Familial chylomicronemia syndrome (FCS) is a rare autosomal recessive disorder caused by genetic variants affecting the lipoprotein lipase (LPL) pathway, characterized by severe hypertriglyceridaemia with triglyceride levels typically of 10 mmol/L (880 mg/dL) or greater and recurrent episodes of acute pancreatitis

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Inhibition of these mechanisms by copper efflux results in reduced vascular wall tone, increased myocardial fragility, reduced angiogenesis and ultimately myocardial injury (Fig