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Drawbacks include dose-dependent adverse effects and the development of steroid resistance

By comparing with the normal human astrocyte cell line, the result of qRT-PCR and WB demonstrates that GPX8 was highly expressed in GBM cells, including LN-299, A172 and U251 ( Figure 8A )

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The overproduction of ROS may be decreased as a result of antioxidant supplementation, which may also enhance the quality of the semen and increase the likelihood of clinical pregnancy, live births, and decreased miscarriage rates (131)