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Nevertheless, when used appropriately and together with other complementary approaches, it is clear that genetically-modified mice can be very useful tools in understanding the distinct roles of the two ERs in cardiovascular function especially with aging and with fluctuations in endogenous hormonal milieu

Graphical Abstract 1 Introduction Mycotoxins are secondary toxic metabolites naturally produced by certain filamentous fungi

In addition, gut microbiota metabolites derived from dietary polyphenols (e.g., phenolic sulfates) can cross the BBB and directly modulate microglia activity and neuroinflammation (58, 59)