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Interestingly, GFR remained increased even 14 days after cessation of rhIGF-1 therapy compared to placebo-treated controls, suggesting that rhIGF-1 resulted in renal hypertrophy, since the hemodynamic effects should have worn off within 14 days of cessation

Furthermore, the possibility of improved formulations (e.g., injectable forms of anti-obesity drugs and or once weekly verses daily administration) serve to enhance compliance

Importantly, most exogenous MSU injection models primarily reproduce acute inflammatory flares rather than the spontaneous and natural course of human gout (69), whereas hyperuricemia models mainly reflect the metabolic basis of disease initiation and do not directly correspond to typical gouty arthritis attacks

V.BartlettR