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MLKL drives basal resistance to ferroptosis by depleting PUFAs, whereas ACSL4 promotes basal resistance to necroptosis by making the membrane less susceptible to MLKL-driven permeabilization [16, 214]

Omega-3 fatty acids ingested from foods like sardines, walnuts, seaweed oil, and deep-sea fish provide neuroprotective effects by supporting neuronal development and synaptic activity while reducing inflammation over the gutbrain axis (Latifi et al., 2016)

Primers are listed in Supplementary Table 5

tenuifolia and exhibits various pharmacological effects, such as antioxidant [12], anti-inflammatory [13], inhibition of neuronal apoptosis [14], and enhancement of neuroprotection [15]