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Concordantly, some species, like the cavefish highlighted in this review, have evolved metabolic evolutionary changes different from their surface-dwelling counterparts to increase their resilience to oxidative stress via lower ROS and higher antioxidant levels

In addition, fatty acids serve as secondary messengers, receptor ligands, and substrates for post-translational protein modification that contribute to the differentiation and effector function of T cells in the tumor microenvironment

Acknowledgments The authors would like to thank the Long Island University Dassault Systmes Centre of Excellence for their financial and resource support