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After probing with biotinylated anti-2,4-dinitrophenyl hydrazine antibody (Molecular Probes Inc, Eugene, Oregon, USA), streptavidin-biotinylated horseradish peroxidase (Amersham Biosciences, Piscataway, New Jersey, USA) was incubated in the wells

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These cytokines can also cross the blood-brain barrier, driving the severe neuroinflammation responsible for the profound cognitive dysfunction, memory loss, and "brain fog" reported by so many patients