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In multivariable analysis, female sex (aOR 2.74 [95% CI: 1.45, 5.23]), pre-LT opioid use (aOR 3.64 [1.96, 6.84]), and depression (aOR 2.15 [1.01, 4.38]), were significantly associated with high-risk opioid use

Importantly, both the levels and timing of ROS production need to be tightly regulated for efficient wound healing 7

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10.3389/fendo.2021.708838 23 LeiZYangLLeiYYangYZhangXSongQChenGLiuWWuHGuoJJT (2021b) High dose lithium chloride causes colitis through activating F4/80 positive macrophages and inhibiting expression of Pigr and Claudin-15 in the colon of mice