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l carnitine withdrawal A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial for Efficacy of Acetyl-L-carnitine in Patients with Dementia Associated with Cerebrovascular Disease The Acetyl Group Buffering Action

Name: l carnitine withdrawal A Multicenter, Randomized, Double-blind, Placebo-controlled Clinical Trial for Efficacy of Acetyl-L-carnitine in Patients with Dementia Associated with Cerebrovascular Disease The Acetyl Group Buffering Action
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The Acetyl Group Buffering Action of Carnitine Acetyltransferase Offsets Macronutrient Induced Lysine Acetylation of Mitochondrial Proteins ScienceDirect The carnitine system and cancer metabolic plasticity Cell Death & Disease Carnitine metabolic disorders and novel clinical approaches: Mechanistic insights from deficiency management to liver and kidney disease treatment ScienceDirect Chronic oral administration of L carnitine induces testicular injury: in vivo evidence International Urology and Nephrology Springer Nature Link

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The promotion of ferritinophagy by NCOA4 has been confirmed in diseases such as diabetic complications, sepsis, Parkinsons disease, acute kidney injury, cerebral ischemiareperfusion injury and osteoarthritis 75,76,77,78,79,80,81

65 In the heart, we first identified ferroptosis as the major pathogenic mechanism in both doxorubicin- and I/R-induced cardiomyopathy, and we showed that targeting ferroptosis significantly alleviated heart injury in mouse models