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However, this is not because the ketogenic diet is contraindicated (in fact, T2DM may be an appropriate indication for the KD), but because the diet is so effective at reducing blood glucose (as described above) that hypoglycaemia may develop if the pharmacotherapy (previously dosed for higher carbohydrate supply) remains unchanged

aSyn overexpressing transgenic mice show elevated levels of S-nitrosylated Parkin and PINK1 and defects in mitochondrial quality control 79 , whereas aSyn-knockout cells and mice are resistant to the deleterious effects of RNS elicited by exposure to MPP+ or LPS 122

Regarding the dose, differences were observed among acute and chronic supplementation protocols, although this review did not find significant improvements in moderate-intensity exercise performance parameters

The Cochrane Collaborations Tool for Assessing Risk of Bias in Randomised Trials