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It influences anti-inflammatory pathways, including downregulation of cytokines (Tumor Necrosis Factor-alpha and Interleukin-6), which are responsible for promoting tissue swelling and damage

This finding suggests that CARMA1-dependent NF-B signaling is required following the initial priming and polarization of Th17 cells and is essential for completing Th17 differentiation

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This review highlights that given the robust preclinical evidence and high public interest, there is a critical need for well-designed human trials to assess the safety, efficacy, and clinical utility of BPC-157 in musculoskeletal medicine