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Pedrosa, A

doi:10.1056/NEJMoa2412063 5

With rising life expectancy, growing awareness of preventive healthcare, and a booming wellness industry, more Indians are moving beyond reactive medicine toward proactive longevity strategies

They secrete pro-inflammatory mediators and elastase, which induce chondrocyte apoptosis and extracellular matrix (ECM) degradation, thereby promoting the progression of OA ( On one hand, similar to macrophages and other immune cells, neutrophils can secrete interleukin-1 (IL-1), which exacerbates cartilage damage in OA through multiple pathways