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Acute kidney injury (AKI), often caused by ischemiareperfusion, results in the release of IL-1 and neutrophil-derived proteases into the circulation, directly impairing cardiomyocyte contractility and increasing arrhythmia susceptibility

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Finally, ALA/GLA demonstrated notable efficacy in reducing symptoms and functional deterioration measured by the Hi-Ob scale (a historical-objective scale based on clinical history and physical examination), while the multivitamin group showed a less marked improvement