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Negative symptoms, striatal dopamine and model-free reward decision-making in schizophrenia

change in the natural circadian rhythm (88)

These include its comparatively high utilization of oxygen and therefore generation of free radical byproducts, its modest antioxidant defenses, its lipid-rich constitution that provides substrates ready for oxidation, the reducing potential of certain neurotransmitters, and the presence of redox-catalytic metals, like iron and copper (47)

Validating urine-based biomarkers (e.g., cyst-derived exosomal ferroptosis regulators and lipid peroxide metabolites) or circulating signatures that correlate with ADPKD disease stage, cyst growth rate, or response to ferroptosis modulators is urgently needed to guide clinical trial design and patient stratification