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To examine AP1 promoter activity following copper-induced upregulation of FOS , FOSB , JUN , and JUNB , a luciferase reporter assay was performed in HepG2 and HepG2 ATP7B-KO cells

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CAR has emerged as a promising therapeutic target for diabetes, fatty liver disease and alcoholic liver disease, but it has barely been investigated in the context of sepsis

By generating a genome-wide clustered regularly interspaced short palindromic repeats (CRISPR)-based genetic screen and microarray analysis, researchers found that ACSL4 was significantly downregulated in ferroptosis-resistant cell lines