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If you read the big chunk on telomeres, heres a reminder of where were at: cells that dont divide any more but havent managed to kill themselves (which is something we want them to do) enter senescence , which is generally a Bad Thing and is a leading theory on why we age

Moreover, this study revealed for the first time that the downregulation of the mitochondrial biogenesis coactivator PGC-1 and its downstream nuclear factors are linked to mtDNA content in high-fat diet-induced obesity, muscle density loss, mitochondrial and myocardial contractile dysfunction, ROS accumulation, and intracellular Ca 2+ signaling