#dihexa Dihexa | c-Met chemical | CAS 1401708-83-5 Dihexa · Disguised Alpha

Receptor Pharmacology and Signaling Pathways : Characterizing activation of amylin/calcitonin receptors, downstream signaling, and functional readouts in different cell systems

doi:10.1124/jpet.114.218735

Subsequent subchronic dosing in HFD-fed mice revealed that Cagrilintide doses of 3 and 30 nmol/kg produced significant decreases in food intake during the first three days of treatment, but this effect waned over time

* Based on the trial product estimand: estimated efficacy in an idealized scenario in which all patients stayed on treatment and took no other weight loss therapies ** Based on the treatment policy estimand: estimated efficacy regardless of whether patients stayed on treatment or took other weight loss therapies About CagriSema CagriSema is being investigated by Novo Nordisk as a once-weekly subcutaneous injectable treatment for adults with overweight or obesity (REDEFINE program) and as a treatment for adults with type 2 diabetes (REIMAGINE program)