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How the human protocols are structured: Onetime gene transfer dosing (not daily injections) IM injection sites distributed through target muscles Followup over months for functional endpoints Dosing Protocol (Human clinical data only) Protocol A Becker Muscular Dystrophy (Doseescalation cohorts) Low cohort: 6 10 vg/kg total (IM

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Using a cut-off value of 650 ng/ml, NQO1-MS demonstrated 80% sensitivity and 70% specificity, with positive and negative predictive values of 73% and 78%, respectively

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In particular, organotypic brain slice cultures provide an excellent model to study the processes of demyelination and remyelination associated with neurological disease and injury

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