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Description

Most PD cases are sporadic, and it is reported that 5% to 10% of PD may be caused by a single pathogenic mutation (single gene)

Jiang H, He H, Chen Y et al (2017) Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

It is diagnosed through skin biopsy showing reduced intraepidermal nerve fiber density (IENFD) or corneal confocal microscopy showing reduced corneal nerve fiber density