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The BBB surrounded by basal lamina, pericytes, and astrocytic perivascular end-feet and acting together with neurons and glial cells forms the neurovascular unit (NVU) which is crucial for the function of the brain (Zlokovic, 2011)

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doi: 10.1038/cdd.2010.6 155 BirkenmeierGHemdanNYAKurzSBiglMPierohPDebebeTet al

It is evident that NAD + has the capacity to influence the metabolism of glucose and lipids on a systemic level