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The gene, mapping on chromosome 6, has been identified in 2002 in two parallel studies that classified CT2 as the sixth member of the OCT subfamily (Enomoto et al., 2002

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Science 329 (5997), 1306-1311 Spatiotemporal regulation of cell-cycle genes by SHORTROOT links patterning and growth R Sozzani, H Cui, MA Moreno-Risueno, W Busch, JM Van Norman,

Preclinical models have shown that curcumin modulates multiple disease-relevant pathways, including reduction in oxidative stress, suppression of neuroinflammation, and inhibition of amyloid- aggregation