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(See here: Vitamin B12 Deficiency Test) Interruptions in the Methylation Cycle The methylation cycle can be interrupted at various points, either due to nutrient deficiencies or genetic mutations which affect the required enzymes

Watkins PB, Kaplowitz N, Slattery JT, et al

p53 is one of the main factors that orchestrates apoptosis in response to DNA damage, and it controls the fate of hematopoietic cells deficient in both the Fanconi Anaemia ICL DNA repair pathway and the aldehyde-metabolizing enzyme Aldh2 in mice 13

So my expertise has just grown over questioning and just having experience in the general knowledge of really the basic function of the cell and the mitochondria and the immune system