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Nat Biotechnol 15(13):13511357

doi: 10.1002/btm2.10209

We evaluated whether to convert zeros in the data to missing values (NAs) by comparing heritability estimates, fit with the qtl2 R package 79

These findings have shed light on the dysregulation of important cellular processes, such as cell cycle control, DNA repair mechanisms, and cell signaling pathways, contributing to the understanding of how normal cells transform into cancer cells [24]