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Chronic inflammation, another hallmark of PCOS, arises from ROS-mediated activation of redox-sensitive transcription factors, which upregulate proinflammatory cytokines such as TNF-, IL-6, and CRP (71)

1 Introduction Parkinsons disease (PD) is the most common movement disorder and the second most prevalent neurodegenerative disease ( Given the incomplete understanding of PDs underlying pathological mechanisms, current therapeutic strategies primarily offer symptomatic relief rather than halting disease progression

However, JNK inhibitor SP600125 hindered the activation of JNK, leading to decreasing oridonin-mediated apoptosis (153)

Treatments were given on days 34 and 1011 of the estrous cycle, corresponding to natural peaks in endogenous FSH