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Disclosures: Inbal Houri: Nothing to Disclose, Claire Gage: Nothing to Disclose, Hooman Ebrahimi: Nothing to Disclose, Vathany Kulasingam: Nothing to Disclose, Guilherme Cancado: Nothing to Disclose, Kristel Leung: Nothing to Disclose, Bettina Hansen: Nothing to Disclose, Aliya Gulamhusein: Nothing to Disclose, Gideon Hirschfield: Intercept: Consultant, GSK: Consultant, CymaBay: Consultant, Ipsen: Consultant, Falk: Consultant, Pliant: Consultant, Morphogen: Consultant, Roche: Consultant, Mirum: Consultant, Advanz: Consultant, Chemomab: Consultant, Gilead: Consultant, Kowa: Consultant 2451 ABERRANT CYTOKERATIN 7 EXPRESSION BY HEPATOCYTES CAN PREDICT THE DUCTOPENIA GRADE IN PRIMARY BILIARY CHOLANGITIS Hongli Liu 1 Qing-Fang Xiong 1 yandan zhong 1 Du-Xian Liu 1 Ping Huang 1 Xiao-Ning Feng 1 Yu Zhang 2 Yong-Feng Yang 1 , 1 The Second Hospital of Nanjing, Teaching Hospital of Southeast University, 2 The Second Hospital of Nanjing, Teaching Hospital of Southeast University, Background: Aberrant cytokeratin 7 expression by hepatocytes (CK7+Hs) is the hallmark characteristic of cholestasis diseases, especially in ductopenia diseases such as primary biliary cholangitis (PBC)

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, However, later experiments showed that fiber-like cells could elongate in the absence of microtubules