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*Correspondence: Xue-ming Yao, [email protected] Disclaimer All claims expressed in this article are solely those of the authors and do not necessarily represent those of their affiliated organizations, or those of the publisher, the editors and the reviewers

Klatt and Lamas, 2000

However, whilst multiple compounds targeting redox regulation have been reported to slow disease progression in SOD1 G93A mice (Dash et al., 2018), they have subsequently failed to enhance survival or improve motor function in ALS patients in clinical trials