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Pretreatment of RAW 264.7 macrophage cells with GHK-Cu has been shown to significantly decrease ROS levels induced by lipopolysaccharide (LPS), increase levels of SOD activities and total GSH, and decrease levels of TNF- and IL-6 production through the suppression of NF-B p65 and p38 MAPK signaling [22]

Consequently, preventing follicular atresia by inhibiting apoptosis in oocytes and granulosa cells represents a promising strategy for preserving ovarian reserve

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Cancer 8, e001372