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Here we show that the bacterium utilizes two sequential reactions catalyzed by additional effectors to convert PR-Ub into functional ubiquitin

As for the latter, for example, it has been observed that the supernatant of Lactobacillus delbrueckii CU/22 could lead to the apoptosis and necrosis of HT-29 cells, suggesting that careful consideration ought to be involved in choosing probiotics as adjuvant therapy of IBD [9]

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Performing a meta-analysis across 15 adult blood cohorts, while adjusting for sex, we observed that for all 3 reference panels (i.e., GSS-hypo, T-hypo and T-both), naive B-cell, nave CD8+ T-cell and nave CD4+ T-cell fractions decreased with age, whilst corresponding memory fractions increased (Fig