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Possible dose adjustments are also mentioned for UMs

It works by blocking the NNMT enzyme in fat cells and other tissues, which prevents the conversion of nicotinamide to 1-methylnicotinamide

doi: 10.1371/journal.pbio.2006203, PMID: [DOI] [PMC free article] [PubMed] [Google Scholar] 17

While current therapy of diabetes has targeted glucose control, treatment of diabetic complications, for example, neuropathy, aside from striving for good metabolic control has been only symptomatic