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Dysfunction of the thalamocortical connectivity network is considered the basis of migraine pathophysiology

Bethel, M

In high glucose conditions, E2 enhances glycolysis via enhanced AKT kinase activity and suppresses TCA cycle activity, while in low extracellular glucose conditions, E2 stimulates the TCA cycle via the upregulation of PDH activity and suppresses glycolysis to satisfy the energy requirements of the tumor cell (207)