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Systematic reviews identify 36 studies demonstrating that BPC-157 improves functional, structural, and biomechanical outcomes across muscle, tendon, ligament, and bone injuries in preclinical models, with the peptide enhancing collagen synthesis, improving tensile strength, and accelerating cellular proliferation in tendon fibroblasts through FAK-paxillin pathway activation critical for cellular adhesion, migration, proliferation, and survival

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Zinc supplementation may also not be appropriate for those with HIV/AIDS, those taking antibiotics or penicillamine (Cuprimine, Depen), or those with renal (kidney) dysfunction