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GLP-1 medications affect appetite and glucose metabolism but do not directly support liver function or energy production

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One study in Switzerland showed a marked decrease in the number of FISS from 2005 to 2014, when compared to older studies in the same region (Graf et al., 2015, 2016), and the authors of the paper concluded that the introduction of a non-adjuvanted FeLV vaccine in 2007 might have accounted for the decrease (Graf et al., 2018)

These results suggest that lifespan extension is closely linked to TCA cycle and respiratory chain activity