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In advanced atherosclerosis stages, prostaglandin endoperoxide synthase 2 (PTGS2), ACSL4, caspase-1, and NOD-like receptor protein 3 (NLRP3) expression is upregulated, while GPX4 is downregulated

This method offers two key advantages: first, the diffusion-based framework ensures significantly more stable training and more realistic generations compared to GAN models while retaining the capability to generate fine-scale features and enabling ensemble generation

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SOD administration also improved mean arterial pressure and reduced organ injury scores, particularly in the liver and kidneys (Zainumi et al., 2022)