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Human XBP1s and XBP1u expression plasmids were constructed by inserting the CDS of either spliced XBP1 (1131 bp) or 3X human influenza hemagglutinin (HA)-tagged unspliced XBP1 (786 bp) between the SpeI and XhoI restriction sites in pLEX-MCS (pLEX-hXBP1s and pLEX-3HA-hXBP1u)

doi: 10.3390/molecules26040985 266 Guevara-CruzMHernndez-GmezKGCondado-HuertaCGonzlez-SalazarLEPea-FloresAKPichardo-OntiverosEet al

The study also reported that MIN-102 modulated the defective frataxin pathway in the patients thereby restoring the bioenergetic defects in FRDA (Poli et al., 2020)