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There are insufficient high-quality randomised controlled trials to support their use for weight loss

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Comment: Some commenters recommended CMS work with an independent, neutral entity that would serve as a clearinghouse for not only Part D claims data, but other payer claims data as well, and create full transparency to facilitate the exchange of information to identify 340B claims, prevent duplicate discounts across Medicaid and Medicare and other programs, and resolve disputes or other issues

147,148 These limitations underscore the need for rational combination therapies to enhance ICD potency, remodel the TME, and support effective memory T-cell development